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Genital regeneration : ウィキペディア英語版
Genital regeneration
Genital regeneration encompasses various forms of treatment for genital anomalies. The goal of these treatments is to restore form and function to male and female genitalia by taking advantage of innate responses in the body. In order to do this, doctors, such as Wake Forest's Anthony Atala, have experimented with stem cells and extracellular matrix to provide a framework for regenerating missing structures. More research is needed to successfully move the science from laboratory trials to routine procedures.〔("Bioengineered corporal tissue for structural and functional restoration of the penis" ). 2009 Chen, K. Eberli, D. Yoo, J. and Atala, A. 2009 ''Proceedings of the National Academy of Sciences'' 107 No 8, pp. 3346-3350.〕〔("Bone regeneration and stem cells." ) 2011 Arvidson, K. et al. ''Journal of Cellular and Molecular Medicine'' 15, No 4, pp. 718-746.〕
Patients who stand to benefit most from this field are those who have congenital defects, cancer, injuries that have excised parts of their genitalia (most notably soldiers in war), transgender women/men, and men and women wishing to reverse forms of intentional modification such as circumcision. As is the case in most scientific pursuits, these accomplishments might be applied to other forms of regeneration and vice versa as scientists continue to study tissue engineering.
== Autologous cell therapies ==
In the last decade, there have been notable accomplishments in utilizing extracellular matrices (ECM) and stem cells to reconstruct lost tissue. These cover a range of structures including the genitals.〔("Regenerative Medicine: Regrowing Body Parts" ). March 23, 2008 CBS〕 Professor Atala and his group at Wake Forest University's Institute of Regenerative Medicine have successfully regenerated fully functioning rabbit penises that were excised for the sake of the experiment. Autologous cells were attached to a three-dimensional collagen matrix. Once formed, the structure was attached and tested for functionality.〔〔("Engineered Rabbit Penises Raise Human Hopes." ) 2009 Keim, B. ''Wired Science''〕
An Italian doctor named Dr. Cinzia Marchese has successfully reconstructed the inner mucosal lining of congenitally deformed vaginas by using an enzyme to break down the abnormal lining, then inserting stem cells to remodel the walls and restore normal functionality.〔("Italian doctor builds new, more natural vagina" ). 2007 Brown, S. ''Reuters''〕
There are currently no therapies available for men attempting to clinically regenerate structures of the human penis. Also, for women there are no therapies that use autologous cells to regenerate the clitoris, sometimes removed in cases of female genital mutilation.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Genital regeneration」の詳細全文を読む



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